ITM and Alpha-9 Oncology Announce Global Supply Agreement to Support Alpha-9’s Clinical Radiopharmaceutical Development Program

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GARCHING / MUNICH, Germany and VANCOUVER, British Columbia, January 30, 2024 – ITM Isotope Technologies Munich SE (ITM), a leading radiopharmaceutical biotech company, and Alpha-9 Oncology (Alpha-9), a clinical stage biotechnology company developing differentiated and highly targeted radiopharmaceuticals, today announced the signature of a global master clinical supply agreement to support the development of Alpha-9’s Radiopharmaceutical Therapy (RPT) pipeline candidates for the treatment of cancer. Under the terms of the agreement, ITM will supply its medical radioisotope, non-carrier-added Lutetium-177 (n.c.a. 177Lu) for Alpha-9’s Lutetium-based candidates.

“Entering this strategic collaboration with Alpha-9 underscores our belief in the value of developing established beta-emitters such as Lutetium-177, to advance the radiopharmaceutical industry and maximize patient benefit,” commented Steffen Schuster, CEO of ITM. “Our position as the world’s largest supplier of n.c.a. Lutetium-177 make us an ideal partner for Alpha-9. We look forward to working with a company that shares our vision of improving cancer care and outcomes for patients globally.”

“A stable and reliable supply of high-quality isotopes is key to the successful development of our pipeline, and partnering with ITM is a valuable next step in building out our proprietary offering of differentiated and precise  radiopharmaceuticals,” said David Hirsch, M.D., Ph.D., CEO of Alpha-9.

ITM will supply Alpha-9 with its n.c.a. 177Lu for the clinical development of Alpha-9 radiopharmaceutical candidates comprising n.c.a. 177Lu combined with undisclosed targeting molecules. ITM holds a U.S. Drug Master File (DMF) with the Food and Drug Administration (FDA) for n.c.a. 177Lu and has marketing authorization in the EU (brand name EndolucinBeta®).

About Radiopharmaceutical Therapy (RPT)

Radiopharmaceutical Therapy (RPT) is an emerging class of cancer therapeutics, which seeks to deliver radiation directly to the tumor while minimizing radiation exposure to normal tissue. Targeted radiopharmaceuticals are created by linking a therapeutic radioisotope such as Lutetium-177 or Actinium-225 to a targeting molecule (e.g., peptide, antibody, small molecule) that can precisely recognize tumor cells and bind to tumor-specific characteristics, such as receptors on the tumor cell surface. As a result, the radioisotope accumulates at the tumor site and decays, releasing a small amount of ionizing radiation, with the goal of destroying tumor tissue. The precise localization enables targeted treatment with potentially minimal impact to healthy surrounding tissue.

About ITM Isotope Technologies Munich SE

ITM, a leading radiopharmaceutical biotech company, is dedicated to providing a new generation of radiomolecular precision therapeutics and diagnostics for hard-to-treat tumors. We aim to meet the needs of cancer patients, clinicians and our partners through excellence in development, production and global supply. With improved patient benefit as the driving principle for all we do, ITM advances a broad precision oncology pipeline, including two phase III studies, combining the company’s high-quality radioisotopes with a range of targeting molecules. By leveraging our nearly two decades of pioneering radiopharma expertise, central industry position and established global network, ITM strives to provide patients with more effective targeted treatment to improve clinical outcome and quality of life. www.itm-radiopharma.com

About Alpha-9

Alpha-9 Oncology is a clinical stage radiopharmaceutical company developing differentiated and highly targeted radiopharmaceuticals with the potential to meaningfully improve the treatment of people living with cancer. Applying proprietary technologies and deep-foundational expertise, Alpha-9 is on the forefront of engineering bespoke radiopharmaceuticals that are optimized to selectively deliver radiation to tumor sites while minimizing off-target effects. Alpha-9 is advancing a robust pipeline of novel radiopharmaceuticals with a systematic approach to molecule design that offers broad potential for expansion into several validated oncology targets. For more information, please visit www.a9oncology.com.

Notice Regarding Forward-Looking Statements:

This news release contains forward-looking statements within the meaning of the U.S. Private Securities Litigation Reform Act of 1995 and forward-looking information within the meaning of applicable Canadian securities laws (collectively, “forward-looking statements”). The words “may”, “will”, “potential”, “believes” and “if” are intended to identify forward-looking statements, although not all forward-looking statements contain such terms. You are cautioned that such statements are subject to a multitude of risks and uncertainties that could cause actual results, future circumstances, or events to differ materially from those projected in the forward-looking statements. These risks include, but are not limited to: those associated with the success of research and development programs, the ability to raise additional funding, and the need to obtain regulatory approval. Forward-looking statements are made as of the date hereof, and ITM and Alpha-9 disclaim any intention and has no obligation or responsibility, except as required by law, to update or revise any forward-looking statements, whether as a result of new information, future events, or otherwise.

ITM Contact
Corporate Communications    
Gerrit Siegers              
Phone: +49 89 329 8986 1502        
Email: communications@itm-radiopharma.com          

Investor Relations
Ben Orzelek                                                                        
Phone: +49 89 329 8986 100                                           
Email: investors@itm-radiopharma.com

Alpha-9 Contact
Corporate Communications                                               
Stephen Mitchener                                                                        
Phone: +1 617 865 1004                                           
Email: smitchener@a9oncology.com          

NorthStar Medical Radioisotopes and Alpha-9 Oncology Enter Strategic Long-term Agreement for Supply of Actinium-225 (Ac-225)

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Long term, multi-year supply agreement provides Alpha-9 with NorthStar’s high purity non-carrier added (n.c.a.) Ac-225 to be used in Alpha-9’s targeted radiopharmaceutical programs for treatment of solid and liquid tumors.

Agreement will support Alpha-9’s ongoing development and clinical programs in addition to multiple undisclosed discovery-stage programs.

NorthStar is positioned to be one of the first commercial-scale producers of n.c.a. Ac-225 for advancing clinical research and commercial radiopharmaceutical therapy.

BELOIT, Wis., and VANCOUVER, British Columbia, January 8, 2024 – NorthStar Medical Radioisotopes, LLC (“NorthStar”), a global innovator in development, production and commercialization of radiopharmaceuticals used to detect and treat cancer and other serious diseases, and Alpha-9 Oncology Inc. (“Alpha-9”), a clinical stage biotechnology company developing differentiated and highly targeted radiopharmaceuticals for treatment of a range of cancers, today announced a long-term strategic supply agreement for NorthStar to provide Alpha-9 with its non-carrier added (n.c.a.) Ac-225 for use in its development and clinical programs.

“NorthStar, using its advanced, proprietary electron accelerator technology, is on schedule to be one of the first commercial-scale producers of n.c.a. Ac-225. The n.c.a. Ac-225 we produce is free of long-lived radioactive contaminants and byproducts associated with other production methods – contaminants that pose regulatory and waste management challenges for pharmaceutical companies, hospitals, and health systems,” said Frank Scholz, Ph.D., Chief Executive Officer of NorthStar Medical Radioisotopes. “NorthStar’s advanced technology and expertise in isotope production will accelerate Alpha-9’s ability to advance a number of innovative, specialized radiopharmaceuticals to benefit patients with solid tumors and a variety of blood cancers while minimizing unwanted off-target effects. Working together, we believe NorthStar and Alpha-9 have the opportunity to make a difference for patients with serious disease.”

“The Alpha-9 team is well positioned to progress multiple targets into the clinic,” said David Hirsch, MD, Ph.D., Chief Executive Officer of Alpha-9 Oncology. “Robust supply of high-quality Ac-225 will help us advance a new generation of highly effective radiopharmaceuticals with improved tumor uptake and limited off-target exposure. We look forward to working with NorthStar and bringing our molecules to patients.” 

About Alpha-9 Oncology, Inc. (Alpha-9)
Alpha-9 Oncology is a clinical stage, radiopharmaceutical company developing differentiated and highly targeted radiopharmaceuticals with the potential to meaningfully improve the treatment of people living with cancer. Applying proprietary technologies and deep-foundational expertise, Alpha-9 is on the forefront of engineering bespoke radiopharmaceuticals that are optimized to selectively deliver radiation to tumor sites while minimizing off-target effects. Alpha-9 is advancing a robust pipeline of novel radiopharmaceuticals with a systematic approach to molecule design that offers broad potential for expansion into several validated oncology targets. For more information, please visit www.a9oncology.com.

About NorthStar Medical Radioisotopes, LLC (NorthStar)

NorthStar Medical Radioisotopes is a commercial-stage radiopharmaceutical company at the forefront of advancing patient care by utilizing novel technologies to produce commercial-scale radioisotopes that, once attached to a molecule, have the ability to detect and treat cancer and other serious diseases. NorthStar’s expanding industry-leading position in the emerging field of radiopharmaceutical therapy is supported by its unique capabilities in the sophisticated production of radioisotopes, proven management team, and state-of-the-art, environmentally preferable technologies. NorthStar routinely produces copper-67 (Cu-67) and is poised to be the first commercial-scale producer of non-carrier-added (n.c.a.) actinium-225 (Ac-225). The Company’s Radiopharmaceutical Contract Development and Manufacturing Organization (CDMO) services unit provides customized service offerings and specialized radiopharmaceutical expertise to help biopharmaceutical companies rapidly advance their development and commercial programs. For more information about NorthStar’s comprehensive portfolio and patient-focused services, visit: www.northstarnm.com.  

Notice Regarding Forward-Looking Statements:

This news release contains forward-looking statements within the meaning of the U.S. Private Securities Litigation Reform Act of 1995 and forward-looking information within the meaning of applicable Canadian securities laws (collectively, “forward-looking statements”), including statements regarding Alpha-9 advancing a new generation of highly effective radiopharmaceuticals, NorthStar’s commercial-scale production of n.c.a. Ac-225, and other statements about Alpha-9’s and NorthStar’s products and the potential thereof. The words “may”, “will”, “potential”, “believes” and “if” are intended to identify forward-looking statements, although not all forward-looking statements contain such terms. You are cautioned that such statements are subject to a multitude of risks and uncertainties that could cause actual results, future circumstances, or events to differ materially from those projected in the forward-looking statements. These risks include, but are not limited to: those associated with the success of research and development programs, the ability to raise additional funding, and the need to obtain regulatory approval. Forward-looking statements are made as of the date hereof, and NorthStar and Alpha-9 disclaim any intention and has no obligation or responsibility, except as required by law, to update or revise any forward-looking statements, whether as a result of new information, future events, or otherwise.

For NorthStar Medical Radioisotopes, LLC

Corporate:

Alison Hess

Vice President, Chief of Staff  

608-295-9806

ahess@northstarnm.com

Investor Relations:

Paul Estrem

Executive Vice President and Chief Financial Officer

608-987-8318

pestrem@northstarnm.com

For Alpha-9 Oncology, Inc.

Stephen Mitchener

Chief Business Officer

617-865-1004

smitchener@a9oncology.com

Alpha-9 Theranostics Strengthens its Scientific Expertise with Key Appointments to Leadership Team and Scientific Advisory Board

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Dr. Jutta Wanner to lead R&D discovery efforts and support the continued expansion of Alpha-9’s differentiated radiopharmaceutical pipeline

Dr. Jason Lewis and Dr. Thomas Ruth, internationally recognized leaders in the radiopharmaceutical space, to join Alpha-9’s SAB

BOSTON, Mass. and VANCOUVER, British Columbia, March 7, 2023 – Alpha-9 Theranostics, a clinical stage biotechnology company developing differentiated and highly targeted radiopharmaceuticals, today announced the appointment of Jutta Wanner, Ph.D. as Senior Vice President of Drug Discovery. The company also announced the appointments of Jason Lewis, Ph.D. and Tom Ruth, Ph.D. to the newly formed Scientific Advisory Board.

“We are thrilled to welcome these experts to our team,” said David Hirsch, M.D., Ph.D., CEO of Alpha-9. “The addition of their knowledge and experience will accelerate our company’s growth.”

Dr. Jutta Wanner, who brings over 20 years of drug discovery experience, will lead discovery and early stage development of the company’s programs and oversee the expansion of Alpha-9’s pipeline. Her experience includes leading small molecule and targeted drug conjugate projects as the CSO and CTO of multiple biotechnology organizations, as well as a decade at Hoffmann-La Roche in a number of drug discovery roles.

“I have followed the developments in radiopharmaceuticals over the past decade as the field has made significant breakthroughs in creating highly efficacious and tolerable agents. I truly believe that radiopharmaceuticals will provide novel treatment options for patients,“ said Dr. Wanner. “Alpha-9 has a well-rounded and knowledgeable team, exciting data, and the resources to efficiently bring the next set of compounds into the clinic and beyond. I am excited to build out the R&D team and look forward to moving into our new lab space.”

Dr. Jason Lewis brings deep expertise in the development and translation of radiopharmaceuticals from decades of research developing small- and biomolecule-based therapeutics and diagnostics. He is the Emily Tow Jackson Chair at Memorial Sloan Kettering Cancer Center in New York as well as the Vice Chair for Research for the Department of Radiology, Chief Attending of the Radiochemistry and Imaging Sciences Service, and Co-Director of the Radiochemistry and Molecular Imaging Probe Core Facility.

Dr. Thomas Ruth brings more than five decades of experience in the production and application of radioisotopes for research in the physical and biological sciences. He is an Emeritus Senior Research Scientist at TRIUMF and Emeritus Senior Scientist at the British Columbia Cancer Research Centre. A leader in the production and application of radioisotopes for research in the physical and biological sciences, he has served on a multitude of national and international committees (USDOE, NAS, IAEA). Dr. Ruth was the Director for the UBC/TRIUMF PET Program for over 20 years, during which time he oversaw the installation of multiple cyclotrons and PET scanners at UBC. Dr. Ruth is also a Fellow of the Royal Society of Canada.

About Alpha-9

Alpha-9 Theranostics is a clinical stage, radiopharmaceutical company developing differentiated and highly targeted radiopharmaceuticals with the potential to meaningfully improve the treatment of people living with cancer. Applying proprietary technologies and deep-foundational expertise, Alpha-9 is on the forefront of engineering bespoke radiopharmaceuticals that are optimized to selectively deliver radiation to tumor sites while minimizing off-target effects. Alpha-9 is advancing a robust pipeline of novel radiopharmaceuticals with a systematic approach to molecule design that offers broad potential for expansion into several validated oncology targets. For more information, please visit www.alpha9tx.com.

Alpha-9 Theranostics Announces Oversubscribed $75 Million Series B Financing to Advance Portfolio of Radiopharmaceuticals for Cancer

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Company is developing bespoke radiopharmaceuticals with capital efficient and rapid approach

Proceeds to support progression of five candidates into the clinic, expansion of early-stage programs, accelerated growth of team, and completion of purpose-built research facilities

BOSTON, Mass. and VANCOUVER, British Columbia, December 14, 2022 – Alpha-9 Theranostics Inc., a clinical stage company developing differentiated and highly targeted radiopharmaceuticals with the potential to meaningfully improve the treatment of people living with cancer, today announced an oversubscribed $75 million Series B financing. The round was led by Nextech Invest, with participation from Frazier Life Sciences, Samsara BioCapital and Quark Venture in addition to existing investors Longitude Capital and BVF Partners.

Alpha-9 is engineering highly effective, bespoke radiopharmaceuticals for the treatment of solid and hematologic malignancies. These molecules are optimized to selectively deliver radiation to tumor sites while minimizing off-target effects. The Series B funding will support advancement of the company’s five programs into the clinic over the next two years while expanding its early-stage programs.

“We have always believed in the company, its founders, and the potential for radiotherapies to effectively address a wide range of cancers,” said David Hirsch, M.D., Ph.D., Chief Executive Officer of Alpha-9. “Our team has done excellent work progressing our pipeline of novel radiopharmaceuticals over the last year, and we are excited to have the support of these top-tier investors. With this new investor partnership, we are well positioned to progress multiple targets into the clinic, harnessing the potential of radiopharmaceuticals to realize more effective treatments for people living with cancer.”

Alpha-9’s systematic approach to radiotherapeutic design is fueled by a toolbox of technologies and chemistries, which offers broad potential for expansion into a multitude of oncology targets. Leveraging its founders’ deep expertise in the modification of peptides and small molecules, Alpha-9 tailors each component of its radiopharmaceuticals – binder, linker, chelator and radioisotope – to improve the molecule’s overall performance. The company’s development process includes human imaging and dosimetry studies, which provide early feedback on molecule design. This approach is capital efficient and rapid, resulting in de-risked compounds prior to later-stage clinical evaluation.

“The radiopharmaceutical field has evolved over the past several years, attributable to scientific advances, translational data and strong clinical efficacy,” said Melissa McCracken, Ph.D., Partner at Nextech Invest and Alpha-9 Board member. “This new generation of radiopharmaceuticals shows improved tumor uptake with limited off-target exposure, resulting in drugs that have better safety and efficacy profiles in the clinic. We are excited by the progress Alpha-9 has demonstrated and are proud to support expansion of its programs and facilities.”

In addition to advancing the clinical pipeline, the Series B will enable Alpha-9 to grow its team to support discovery programs. Furthermore, the company will complete the build-out of its research facilities in Vancouver, BC, which will house the chemistry, biology, translational research and radiochemistry teams, as well as support product formulation. Alpha-9 has also invested in radioisotope supply through agreements with multiple lutetium and actinium partners. The company looks forward to expanding these relationships with the Series B proceeds.

The company, headquartered in both Boston and Vancouver, was founded in 2019 by François Bénard, M.D., Kuo-Shyan Lin, Ph.D., and David Perrin, Ph.D., leading researchers from BC Cancer and the University of British Columbia with deep expertise in the modification of peptides and small-molecules to create novel radiopharmaceuticals.

Melissa McCracken, Ph.D., Partner at Nextech Invest, Patrick Heron, M.B.A., Managing Partner at Frazier Life Sciences, Cory Freedland, Ph.D., Partner at Samsara BioCapital, and Matthew Young, M.B.A., Managing Director at Longitude Capital will join the Alpha-9 Board of Directors, along with Darcy Mootz, Ph.D., Site Head at Amunix, a Sanofi Company (Chief Business Officer prior to sale), who will join as a Board advisor.

About Alpha-9 Theranostics

Alpha-9 Theranostics is a clinical stage, radiopharmaceutical company developing differentiated and highly targeted radiopharmaceuticals with the potential to meaningfully improve the treatment of people living with cancer. Applying proprietary technologies and deep-foundational expertise, Alpha-9 is on the forefront of engineering bespoke radiopharmaceuticals that are optimized to selectively deliver radiation to tumor sites while minimizing off-target effects. Alpha-9 is advancing a robust pipeline of novel radiopharmaceuticals with a systematic approach to molecule design that offers broad potential for expansion into several validated oncology targets. Alpha-9 was founded by researchers from the University of British Columbia and BC Cancer, with the goal of improving the lives of patients affected by metastatic cancers. For more information, please visit www.alpha9tx.com.

Media Contact

Gracelyn Nguyen, Verge Scientific Communications
gnguyen@vergescientific.com

Eckert & Ziegler and Alpha-9 Sign Actinium-225 (Ac-225) Reservation Agreement

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BOSTON, Mass. and VANCOUVER, British Columbia, October 13, 2022 – Eckert & Ziegler (ISIN DE0005659700, SDAX) and Alpha-9 Theranostics Inc. (Alpha-9), a radiopharmaceutical company with offices in Vancouver and Boston, have signed an agreement for the preferred supply of GMP grade Actinium-225. The reservation gives Alpha-9 priority access to Eckert & Ziegler’s high-purity, non-carrier-added Actinium-225, a radionuclide used for the next generation of therapeutic radiopharmaceuticals.

“Following the successful completion of our supply agreement for Lutetium-177 earlier this year, we are pleased to further expand our relationship with Alpha-9 and contribute to innovation in cancer treatment through the supply of Actinium-225, a promising therapeutic radioisotope” explained Dr. Harald Hasselmann, Executive Director and responsible for the Medical segment of Eckert & Ziegler. “Access to Actinium-225 has been limited in the past which slowed down clinical research and commercial use. With the construction of our new Ac-225 production facility, we are addressing this situation and expect to be able to offer the radioisotope in limited quantities in the fourth quarter of 2023 and in larger quantities in the second half of 2024.”

“The radionuclide Actinium-225 is a key component of the therapeutic compounds in our portfolio and access is crucial to drive our development and clinical research” stated David Hirsch, CEO of Alpha-9. “We are pleased to extend our collaboration with Eckert & Ziegler to achieve our goal of improving the lives of patients affected by metastatic cancers.”

Actinium-225 is used as an active substance in cancer treatment. The radioisotope emits powerful, high-energy alpha particles with short penetration depths that enable precise treatment of tumor cells, including elusive micrometastases, with minimal impact on surrounding healthy tissue. For this purpose, Actinium-225 is combined with a suitable carrier (e.g., an antibody or peptide) that specifically binds to cancer cells, thereby selectively targeting them. Currently, radiopharmaceuticals based on Actinium-225 are being tested in many clinical indications, including prostate tumors, colorectal cancer and leukemia. Experts expect the demand for Actinium-225 to increase exponentially over the next decade.

About Eckert & Ziegler.

Eckert & Ziegler Strahlen- und Medizintechnik AG with more than 900 employees is one of the world’s largest providers of isotope-related components for nuclear medicine and radiation therapy. The company offers services for radiopharmaceuticals at its worldwide locations, from early development to commercialization. Eckert & Ziegler shares (ISIN DE0005659700) are listed in the SDAX index of Deutsche Börse. Contributing to saving lives.

About Alpha-9 Theranostics

Alpha-9 Theranostics is a clinical stage, radiopharmaceutical company developing imaging and therapeutic molecules for solid and hematologic malignancies. Using proprietary technology and the Company’s expertise, these differentiated molecules have the potential to meaningfully extend patients’ lives with favorable safety profiles.

Alpha-9 Starts Construction of Research Facility in Vancouver

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VANCOUVER, British Columbia, October 1, 2022 – Alpha-9 Theranostics, Inc. announced today that it has authorized construction of an in-house research facility in Vancouver, British Columbia.

The fit-for-purpose facility will house chemistry, biology and radiochemistry R&D teams, and will accelerate Alpha-9’s discovery efforts for new peptide and small molecule-based radiopharmaceuticals. The facility will house hot cells to develop Alpha-9’s radiolabeling processes at clinical scale for subsequent transfer to the company’s GMP manufacturing partners, facilitating clinical translation of the company’s product candidates. Planning has been underway since earlier this year and the research facilities are expected to be operational by 2H 2023

Isotopia Molecular Imaging and Alpha-9 Theranostics Announce Lutetium-177 Supply Agreement

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BOSTON, Mass. and VANCOUVER, British Columbia, May 23, 2022 – Isotopia Molecular Imaging and Alpha-9 Theranostics, are pleased to announce the signing of a global clinical supply agreement that provides Alpha-9 with Isotopia’s medical radioisotope no-carrier-added lutetium-177 for the preclinical and clinical development of Alpha-9’s radiopharmaceutical pipeline.

“We are pleased to contribute to Alpha-9’s exciting program,” comments Director of BD Keren Moshkoviz. “Using our  well established experience in radioisotope global production and supply, we aim to further support the development of Targeted Radionuclide Therapies to improve clinical outcomes for patients worldwide.”

Alpha-9 is excited to partner with Isotopia and is committed to developing its pipeline of radiopharmaceuticals for the benefit of patients.

Eckert & Ziegler to Supply Canadian Alpha-9 Theranostics with Lutetium-177 for Clinical Trials

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BOSTON, Mass. and VANCOUVER, British Columbia, March 23, 2022 – Eckert & Ziegler (ISIN DE0005659700, TecDAX) has executed with the Canadian biotech company Alpha-9 Theranostics Inc. (Alpha-9) a clinical supply agreement for Eckert & Ziegler’s medical radioisotope Lutetium-177 (non-carrier-added 177Lu). The isotope will be used for the clinical development of Alpha-9´s investigational drugs.

Eckert & Ziegler has developed a unique, stable and reliable method to produce a highly pure form of n.c.a. Lu-177 which will be used by Alpha-9 for the clinical trials of its therapeutic candidates for solid and hematologic malignancies.

Lutetium-177 is a beta emitting radioisotope that can be linked to a variety of tumor specific drugs which then incorporates the radiating element of the radioisotope into the tumor cells.

“The supply contract with Canada-based Alpha-9 further underlines our outstanding expertise in supplying isotopes to the pharmaceutical industry. With production sites in Europe, Asia, and North America, we are excellently positioned to meet the growing demand for relevant isotopes and the associated development and production services,” explained Dr. Harald Hasselmann, Executive Director and responsible for the Medical segment of Eckert & Ziegler. “Our recently concluded joint venture with Atom Mines LLC provides us with excellent access to the scarce and indispensable precursor ytterbium-176, enabling us to supply lutetium-177 n.c.a. in highest purity and reliably to pharmaceutical customers worldwide.”

Alpha-9 is committed to developing its portfolio and exploring potential therapies to help patients. Alpha-9 is looking forward to its partnership with Eckert Ziegler and the potential that this partnership creates to advance radioligand therapy.

Targeted radionuclide therapy with Lutetium-177, currently under late-stage clinical development for several types of cancer, may provide a valuable alternative treatment option in the field of precision oncology.

About Eckert & Ziegler.

Eckert & Ziegler Strahlen- und Medizintechnik AG with more than 900 employees is one of the world’s largest providers of isotope-related components for nuclear medicine and radiation therapy. The company offers services for radiopharmaceuticals at its worldwide locations, from early development to commercialization. Eckert & Ziegler shares (ISIN DE0005659700) are listed in the TecDAX index of Deutsche Börse. Contributing to saving lives.

About Alpha-9 Theranostics

Alpha-9 Theranostics is a clinical stage, radiopharmaceutical company developing imaging and therapeutic molecules for solid and hematologic malignancies. Using proprietary technology and the Company’s expertise, these differentiated molecules have the potential to meaningfully extend patients’ lives with favorable safety profiles.

Alpha-9 Theranostics Announces $11 Million Series A Financing to Advance Portfolio of Radiotherapeutics and Diagnostics

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VANCOUVER, British Columbia, April 28, 2021 — Alpha-9 Theranostics Inc. announced today an $11 million Series A financing to advance a portfolio of novel radiotherapeutics and diagnostics. Longitude Capital led the financing with participation from BVF Partners L.P. and insiders. “We are delighted that Longitude and BVF are investing in Alpha-9,” said Simon Pimstone, MD, PhD, Chairman of the Board of Directors. “These high-quality investors share our conviction in the promise of radiotherapeutics and diagnostics.” David Hirsch, MD, PhD of Longitude Capital remarked, “Alpha9 is an exciting company, founded by leaders in the field, with a growing portfolio of novel assets. We believe that radiotherapeutics have the potential to deliver on the promise of precision oncology and we look forward to working with the Alpha-9 team to advance multiple programs into clinical trials.”

About Alpha-9

Alpha-9 Theranostics is a clinical stage, radiopharmaceutical company developing imaging and therapeutic molecules for solid and hematologic malignancies. Using proprietary technology and the Company’s expertise, these differentiated molecules have the potential to meaningfully extend patients’ lives with favorable safety profiles. Alpha-9 was founded by researchers from the University of British Columbia and BC Cancer, with the goal of improving the lives of patients affected by metastatic cancers. For more information, please visit www.alpha9tx.com.

About Longitude Capital

Longitude Capital is a leading healthcare venture capital firm that invests in transformative biotechnology, medical technology and health solutions companies seeking to improve clinical outcomes, enhance quality of life, and drive efficiency of healthcare delivery. Founded in 2006, Longitude Capital invests in both privately held and publicly traded companies through a variety of investment approaches. Longitude Capital has offices in Menlo Park, CA, Greenwich, CT, and Boston, MA. For more information, please visit www.longitudecapital.com or LinkedIn.