We are seeking driven, creative, and entrepreneurial individuals to help shape our company. At Alpha-9, you’ll find a culture of collaboration, transparency, and innovation. We are passionate about developing new medicines to help people living with cancer, and we are looking to add to our growing team.

Open Positions

Senior Scientist, Chemistry, Peptides

About Us

Alpha-9 Theranostics is a clinical-stage biotechnology company developing radiopharmaceuticals that image and treat solid and hematologic malignancies. Alpha-9 has a portfolio of molecules entering clinical trials and a robust pipeline of additional targets for future development. Building on years of radiopharmaceutical expertise and with backing from leading healthcare investors, Alpha-9 is committed to developing novel radiopharmaceuticals that meaningfully extend patients’ lives.

Position Summary

Alpha-9 is seeking Senior Scientists to join our Chemistry group.  The ideal candidate will have hands-on experience in synthetic organic chemistry, including in the synthesis, isolation and purification of either small molecules, peptides or peptidomimetics. This person will be responsible for synthesizing peptides/peptidomimetic building blocks and precursors for radiopharmaceutical product candidates. Expertise in solid-phase peptide synthesis and the optimization of peptide ligands required.

We are an early-stage company, so you will have the opportunity to participate cross-functionally and contribute to the build-out and set-up of new laboratory facilities.  The ideal candidate will have multi-tasking ability and a desire to strive in a fast-paced environment.

Some specific duties and tasks include, but are not limited to, the following:

  • Design and synthesis of peptides/peptidomimetics or small molecule-based building blocks and drug substances for radiopharmaceutical development
  • Working closely cross-functionally to achieve project goals
  • Supervision and mentoring of junior scientists
  • Compound characterization employing LC-MS/MS, GC-MS, HPLC and NMR
  • Lead project discussions and present results in team meetings
  • Key participant in the writing of patent applications
  • Maintenance of clear and accurate lab records, adherence to all safety and compliance requirements

Qualifications

  • PhD in Chemistry or related area with 5+ years of relevant industrial drug discovery experience
  • Solid understanding and practical experience in peptide drug discovery
  • Solid experience in modern synthetic and analytical techniques
  • Excellent observational, organizational, data management, and documentation skills

What’s in it for you

  • Full extended health benefits
  • Competitive salary, annual bonus, and equity
  • 20 vacation days
  • 17 holidays
  • 5 sick days
  • Group Registered Retirement Savings Plan with 5% employer match
  • Commuter reimbursement
  • Long term disability
  • Life insurance
  • Impactful and rewarding work

Schedule

  • Full Time Permanent

Location: Vancouver

Timing: ASAP

Senior Manager/Associate Director, Program Management

About Us:

Alpha-9 Theranostics is a clinical-stage biotechnology company developing radiopharmaceuticals that image and treat solid and hematologic malignancies. Alpha-9 has a portfolio of molecules entering clinical trials and a robust pipeline of additional targets for future development. Building on years of radiopharmaceutical expertise and with backing from leading healthcare investors, Alpha-9 is committed to developing novel radiopharmaceuticals that meaningfully extend patients’ lives.

Position Summary:

Alpha-9 is seeking a Senior Manager/Associate Director of Program Management to lead program management activities for several early-stage radiopharmaceutical cancer therapeutics from IND-enabling studies through clinical trials. This role will ensure organizational alignment and oversee program execution, as well as foster team building and a collaborative environment and is responsible for working closely with team members to forecast key milestones and decision points and deliver program objectives. Position can be located in Boston, MA or San Francisco, CA.

Some specific duties and tasks include, but are not limited to, the following:

  • Lead cross-functional project teams to execute drug development projects from IND-enabling studies through early clinical trials.
  • Develop and maintain detailed project plans, timelines, and budgets, ensuring efficient resource allocation and adherence to project milestones.
  • Collaborate closely with key stakeholders, including R&D, Clinical Development, Clinical Operations and CMC Operations teams to align project goals and objectives.
  • Identify strategic decision points and facilitate cross-functional reviews to drive progress and consensus.
  • Monitor project progress and identify potential risks, proactively implementing mitigation strategies to ensure successful project outcomes.
  • Perform detailed reviews of study reports and regulatory filings to ensure accuracy and consistency.
  • Communicate project updates and status reports to senior management and relevant stakeholders.

Qualifications:

  • BS or advanced degree in a scientific discipline or related field.
  • Minimum of 8 years of clinical operations or related experience in the biotechnology or pharmaceutical industry.
  • Minimum of 3 years of experience in Project/Program Management within the biotechnology or pharmaceutical industry.
  • Proven track record of successfully managing complex projects from early-development stages through clinical proof of concept.
  • Strong understanding of clinical trial processes; previous experience with IND-enabling study requirements is a plus.
  • Strong experience in early-stage clinical trials and progressing them to later stages.
  • Excellent leadership and team management skills, with the ability to motivate and guide cross-functional teams.
  • Familiarity with domestic and international regulatory requirements (FDA, EMA, etc.) for drug development.
  • Demonstrated ability to influence others and negotiate, strong problem-solving abilities.
  • Exceptional communication skills, ability to build strong relationships at all levels of the organization.

What’s in it for you:

  • Competitive Salary, Bonus, and Equity
  • Medical, Dental and Vision Benefits
  • HSA and FSA available
  • Commuter Reimbursement
  • Retirement plan with employer match up to 3%
  • 20 vacation days
  • 17 Holidays
  • 5 Sick Days
  • Long Term Disability
  • Life Insurance
  • Impactful rewarding work

Computational Scientist

About Us:

Alpha-9 Theranostics is a clinical-stage biotechnology company developing radiopharmaceuticals that image and treat solid and hematologic malignancies. Alpha-9 has a portfolio of molecules entering clinical trials and a robust pipeline of additional targets for future development. Building on years of radiopharmaceutical expertise and with backing from leading healthcare investors, Alpha-9 is committed to developing novel radiopharmaceuticals that meaningfully extend patients’ lives.

Position Summary

Alpha-9 is seeking a Computational Scientist with proven track record of impacting drug discovery projects. The ideal candidate will have excellent knowledge and skills in a variety of computational tools and methodologies including docking, virtual screening, molecular dynamics, free energy perturbation, homology modeling, pharmacophore elucidation, and bioinformatics. Experience with target selection, small molecule and peptide drug discovery is a plus.

Some specific duties and tasks include, but are not limited to, the following:

  • Provide technical knowledge and input to project teams to drive decision making in target selection and drug discovery projects.
  • Identify and implement novel computational chemistry/science algorithms, technologies, and workflows.
  • Implement AI/machine learning approaches to enhance drug discovery efforts.
  • Establish strategies, develop workflows and cross-functional collaboration.
  • Provide coaching and mentoring to team members.
  • Routinely engage with Program Leads/Scientists to support and enable program progression in a timely manner.

Qualifications:

  • PhD in computational chemistry, bioinformatics, statistics, mathematics, computer science, computational biology, or a related field with 3+ years of relevant experience in pharma/biotech
  • Familiarity with state-of-the-art computational chemistry software, such as Schrödinger Suite, MOE, or similar tools
  • Proficient in at least one general purpose programming/data science languages including but not limited to R, Python, Julia
  • A team player with excellent interpersonal skills and a strong passion for the discovery of targeted therapies in a fast-paced start-up environment

What’s in it for you:

  • Full extended health and dental benefits
  • Competitive Salary, Bonus, and Equity
  • Commuter Reimbursement
  • Group Registered Retirement Savings Plan with employer matching.
  • 20 vacation days
  • 17 Holidays
  • 5 Sick Days
  • Long Term Disability
  • Life Insurance
  • Impactful rewarding work

Location: Vancouver, BC

About Us:

Alpha-9 Theranostics is a clinical-stage biotechnology company developing radiopharmaceuticals that image and treat solid and hematologic malignancies. Alpha-9 has a portfolio of molecules entering clinical trials and a robust pipeline of additional targets for future development. Building on years of radiopharmaceutical expertise and with backing from leading healthcare investors, Alpha-9 is committed to developing novel radiopharmaceuticals that meaningfully extend patients’ lives.

Position Summary:

Alpha-9 is seeking a Senior Manager/Associate Director of Program Management to lead program management activities for several early-stage radiopharmaceutical cancer therapeutics from IND-enabling studies through clinical trials. This role will ensure organizational alignment and oversee program execution, as well as foster team building and a collaborative environment and is responsible for working closely with team members to forecast key milestones and decision points and deliver program objectives. Position will be located in Vancouver, BC.

Some specific duties and tasks include, but are not limited to, the following:

  • Lead cross-functional project teams to execute drug development projects from IND-enabling studies through early clinical trials.
  • Develop and maintain detailed project plans, timelines, and budgets, ensuring efficient resource allocation and adherence to project milestones.
  • Collaborate closely with key stakeholders, including R&D, Clinical Development, Clinical Operations and CMC Operations teams to align project goals and objectives.
  • Identify strategic decision points and facilitate cross-functional reviews to drive progress and consensus.
  • Monitor project progress and identify potential risks, proactively implementing mitigation strategies to ensure successful project outcomes.
  • Perform detailed reviews of study reports and regulatory filings to ensure accuracy and consistency.
  • Communicate project updates and status reports to senior management and relevant stakeholders.

Qualifications:

  • BS or advanced degree in a scientific discipline or related field.
  • Minimum of 8 years of clinical operations or related experience in the biotechnology or pharmaceutical industry.
  • Minimum of 3 years of experience in Project/Program Management within the biotechnology or pharmaceutical industry.
  • Proven track record of successfully managing complex projects from early-development stages through clinical proof of concept.
  • Strong understanding of clinical trial processes; previous experience with IND-enabling study requirements is a plus.
  • Strong experience in early-stage clinical trials and progressing them to later stages.
  • Excellent leadership and team management skills, with the ability to motivate and guide cross-functional teams.
  • Familiarity with domestic and international regulatory requirements (FDA, EMA, etc.) for drug development.
  • Demonstrated ability to influence others and negotiate, strong problem-solving abilities.
  • Exceptional communication skills, ability to build strong relationships at all levels of the organization.

What’s in it for you:

  • Full extended health and dental benefits
  • Competitive Salary, Bonus, and Equity
  • Commuter Reimbursement
  • Group Registered Retirement Savings Plan with employer matching.
  • 20 Vacation Days
  • 17 Holidays
  • 5 Sick Days
  • Long Term Disability
  • Life Insurance
  • Impactful rewarding work

About Us:

Alpha-9 Theranostics is a clinical-stage biotechnology company developing radiopharmaceuticals that image and treat solid and hematologic malignancies. Alpha-9 has a portfolio of molecules entering clinical trials and a robust pipeline of additional targets for future development. Building on years of radiopharmaceutical expertise and with backing from leading healthcare investors, Alpha-9 is committed to developing novel radiopharmaceuticals that meaningfully extend patients’ lives.

Position Summary:

Alpha-9 is seeking an Associate Scientist to join our Biology group. The ideal candidate will have extensive hands-on experience and skills in Surface Plasmon Resonance, especially for characterization of molecular interactions between target of interest and radiopharmaceutical ligands (especially for small molecules or peptide-based molecules). Experience with membrane protein purification is a plus, but not mandatory.

Some specific duties and tasks include, but are not limited to, the following:

  • Responsible for operating and maintaining the SPR equipment.
  • Contribute to the setup and validation of the SPR experiment and procedures.
  • Plan, optimize and perform characterization of binding moieties to develop radiopharmaceutical across the entire pipeline (binding affinity, binding kinetic, specificity)
  • Contribute to data analysis and report experimental results to project teams.
  • Maintenance of clear and accurate lab records, adherence to all safety and compliance requirements

Qualifications:

  • Hands-on experience using SPR (setup, development, optimization and execution of assays)
  • BS, MS. Or PhD degree in Molecular biology, Biochemistry, Protein engineering or any related discipline with 2-5+ years of related industrial experience
  • Solid understanding of and hands-on experience in the analysis of molecular interactions with multiple targets, with preferred experience with small molecules or peptides-based ligands
  • Knowledge in membranous protein purification is an asset but not mandatory
  • Experience in radiopharmaceutical discovery preferred, but not required
  • Excellent observational, organizational, data management, and documentation skills
  • A team player with excellent interpersonal skills and a strong passion for the discovery of targeted therapies in a fast-paced start-up environment

What’s in it for you:

  • Full extended health and dental benefits
  • Competitive Salary, Bonus, and Equity
  • Commuter Reimbursement
  • Group Registered Retirement Savings Plan with 5% employer match
  • 20 vacation days
  • 18 Holidays
  • 5 Sick Days
  • Long Term Disability
  • Life Insurance
  • Impactful rewarding work

Employment Type

About Us:

Alpha-9 Theranostics is a clinical-stage biotechnology company developing radiopharmaceuticals that image and treat solid and hematologic malignancies. Alpha-9 has a portfolio of molecules entering clinical trials and a robust pipeline of additional targets for future development. Building on years of radiopharmaceutical expertise and with backing from leading healthcare investors, Alpha-9 is committed to developing novel radiopharmaceuticals that meaningfully extend patients’ lives.

Position Summary:

Alpha-9 is seeking a Senior Director, Discovery to oversee all functions of our Discovery group in Vancouver. The ideal candidate will have a proven track record of effectively leading oncology discovery functions in a pharma/biotech setting to reach discovery milestones for small molecule, peptide, radiopharmaceuticals or drug-conjugate discovery projects.

Some specific duties and tasks include, but are not limited to, the following:

  • Identify new assets to add to our portfolio. Reporting to the SVP of Research, the person in this position will lead and oversee research into potential new internal and external programs and will remain abreast of current and emerging relevant science and competitive intelligence
  • Interact with all functions to align discovery efforts with the companies goals
  • Liaison between research functions and leadership team
  • Lead functional efforts towards the discovery and development of radiopharmaceuticals
  • Establish strategies, develop workflows and cross-functional collaborations, integrate new technologies
  • Provide coaching and mentoring to team members
  • Routinely engage with functions to support and enable program progression in a timely manner
  • Manage the interpretation, data analysis and preparation of internal and external reports and communicate project progress to internal stakeholders and external collaborators

Qualifications:

  • A PhD in Biology, Biochemistry, Pharmacology, Chemistry or related area with 10+ years of industrial experience and a proven track record of scientific excellence and creativity
  • Proven track record of effectively leading across functions in discovery settings in industry to reach company milestones
  • Experience in radiopharmaceutical discovery preferred, but not required
  • Excellent observational, organizational, data management, and documentation skills
  • A team player with excellent interpersonal skills and a strong passion for the discovery of targeted therapies in a fast-paced start-up environment

What’s in it for you:

  • Full extended health and dental benefits
  • Competitive Salary, Bonus, and Equity
  • Commuter Reimbursement
  • Group Registered Retirement Savings Plan with 5% employer match
  • 20 vacation days
  • 18 Holidays
  • 5 Sick Days
  • Long Term Disability
  • Life Insurance
  • Impactful rewarding work

Schedule: Full-Time Permanent

Location: Vancouver

Timing: ASAP

About Us:

Alpha-9 Theranostics is a clinical-stage biotechnology company developing radiopharmaceuticals that image and treat solid and hematologic malignancies. Alpha-9 has a portfolio of molecules entering clinical trials and a robust pipeline of additional targets for future development. Building on years of radiopharmaceutical expertise and with backing from leading healthcare investors, Alpha-9 is committed to developing novel radiopharmaceuticals that meaningfully extend patients’ lives.

Position Summary:

Alpha-9 is seeking a Project Team Leader (Director or Senior Director level) who will be responsible for managing cross-functional product development planning, submission, and launch, and for coordinating the strategic and operational execution of diagnostic and therapeutic program(s) while adhering to budget, scope, and schedule requirements. The PTL drives the effective development and execution of the development strategies in partnership with the Leadership Team and functional leads of other departments.

Some specific duties and tasks include, but are not limited to, the following:

  • Lead cross-functional Project Team(s) partnering with other functional leads to develop, adapt and drive an integrated product strategy which considers near and long-term cross functional impacts in early to late-stage development programs for diagnostic and therapeutic candidates
  • Works closely to influence, advise and coordinate strategic and operational efforts across all key product development functions, including Research, Pre-Clinical, Clinical, Finance, Regulatory, CMC, Legal, and Business Development to ensure strategic alignment and seamless execution
  • Communicates with the Leadership Team, governance committees and project team to address program needs, issues, resources and recommendations. Ensures that presentations and other product communications are clear and effective
  • Drives team strategic planning, goal setting, prioritization, budgeting and ensures adherence to the plan and strategy
  • Drives risk management, issue identification/resolution and contingency planning
  • Ensures all project deliverables achieve defined project scope, budget and timelines
  • Create a positive team environment that instills trust, encourages an open dialogue and ensures clear/transparent communications to align around the overall goal/vision for the products
  • May include personnel management of one or more Project Manager(s)

Qualifications:

  • MS, PhD or advanced degree in biomedical sciences or one of the disciplines related to drug development
  • Minimum of 15 years of bio-pharmaceutical industry experience with at least 10 years of relevant work experience in the biotechnology or pharmaceutical industry.
  • Demonstrated experience working in oncology product development, including the research, pre-clinical and clinical development and regulatory filings (INDs, NDAs/sNDAs, MAAs) for diagnostic or therapeutic candidates
  • Proven ability to lead, collaborate and influence data-driven strategy planning and implementation
  • A proactive, analytical and strategic thinker, with strong decision-making skills
  • Experience working with academic and corporate partners and leading alliance management activities
  • Proven ability to function effectively across a matrix organization with multiple stakeholders across all levels
  • Strong leadership skills, demonstrated ability to influence others and negotiate, strong problem-solving abilities.
  • Exceptional communication and presentation skills, ability to build strong relationships at all levels of the organization.

What’s in it for you:

  • Full extended health and dental benefits
  • Competitive Salary, Bonus, and Equity
  • Commuter Reimbursement
  • RRSP with an employer match
  • 20 vacation days
  • 18 Holidays
  • 5 Sick Days
  • Long Term Disability
  • Life Insurance
  • Impactful rewarding work

Schedule: Full-Time Permanent

Location: Vancouver

Timing: ASAP

To apply, use the form below.

Don’t see anything that matches your experience? Email us at careers@alpha9tx.com

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