We are seeking driven, creative, and entrepreneurial individuals to help shape our company. At Alpha-9, you’ll find a culture of collaboration, transparency, and innovation. We are passionate about developing new medicines to help people living with cancer, and we are looking to add to our growing team.

Open Positions

Senior Scientist, Radiochemistry

About Us

Alpha-9 Theranostics is a clinical stage, radiopharmaceutical company developing imaging and therapeutic molecules for solid and hematologic malignancies. We have multiple molecules that are headed into clinic within the next few years, and a robust pipeline of additional targets for future development. Using proprietary technology and the Company’s expertise, these differentiated molecules have the potential to meaningfully extend patients’ lives with favorable safety profiles. Alpha-9 was founded by researchers from the University of British Columbia and BC Cancer, with the goal of improving the lives of patients affected by metastatic cancers.

Position Summary

Alpha-9 is seeking a Senior Scientist, Radiochemistry to join our growing organization.  The ideal candidate will have experience developing radiolabeling, and analytical methods for targeted, peptide-based radiopharmaceuticals.  This person will be responsible for developing and delivering novel radiolabeled diagnostic and therapeutic compounds for both pre-clinical and clinical applications.

This position requires a high degree of collaboration, multi-tasking ability, and desire to strive in a fast-paced environment.  You will have the opportunity to contribute to the build-out and set-up of new laboratory facilities, interface with external partners, and mentor more junior staff.

Some specific duties and tasks include, but are not limited to, the following:

  • Develop radiolabeling and manufacturing methods for compounds with imaging and therapeutic applications
  • Work in multidisciplinary teams to define development project goals and timelines
  • Design and conduct radiochemistry experiments leading to robust radiolabeling processes and clinical formulations that meet target product profiles
  • Develop quality control procedures, analytical methods, and specifications for radiopharmaceuticals/API
  • Perform technology transfer of radiolabeling and analytical methods to third party CRO and CDMO partners
  • Support pre-clinical development by radiolabeling compounds for in vitro and in vivo evaluation
  • Troubleshoot, identify unusual results, and design experiments that establish root cause and/or enhance knowledge of the product being developed
  • Write necessary SOPs, development reports, test method protocols, batch records, and regulatory documentation
  • Set up and maintain automated chemistry modules and laboratory equipment
  • Conduct area radiation surveys, contamination control, and radioactive waste management
  • Demonstrate good safety practices and ensure radioprotection standards are upheld

Qualifications

  • PhD/MSc in Radiochemistry, Chemistry, Analytical Chemistry, Nuclear Engineering or equivalent knowledge or experience
  • 5+ years of experience with academic and/or commercial radiopharmaceutical development and production
  • Hands on experience in radiolabeling with radioisotopes used for imaging and therapeutic applications; experience with alpha emitters is a plus
  • Ability to plan and execute complex scientific projects
  • Understanding of regulatory requirements for development of radiopharmaceuticals
  • Demonstrated ability to troubleshoot, identify unusual results and design experiments that establish root cause
  • Excellent observational, organizational, data management, and documentation skills
  • A team player with excellent interpersonal skills and a strong passion for the discovery of targeted therapies in a fast-paced start-up environment

What’s in it for you

  • Full extended health and dental benefits
  • Competitive Salary, Bonus, and Equity
  • Commuter Reimbursement
  • Group Registered Retirement Savings Plan with employer matching
  • 20 vacation days
  • 17 Holidays
  • 5 Sick Days
  • Long Term Disability
  • Life Insurance
  • Impactful rewarding work

Schedule

  • Full Time Permanent

Location: Vancouver

Timing: ASAP

Senior Scientist, Research & Development

About Us

Alpha-9 Theranostics is a clinical-stage biotechnology company developing radiopharmaceuticals that image and treat solid and hematologic malignancies. Alpha-9 has a portfolio of molecules entering clinical trials and a robust pipeline of additional targets for future development. Building on years of radiopharmaceutical expertise and with backing from leading healthcare investors, Alpha-9 is committed to developing novel radiopharmaceuticals that meaningfully extend patients’ lives.

Position Summary

Alpha-9 is seeking a Senior Scientist to drive discovery efforts for new targeted radiopharmaceutical products.  This person will be responsible for one or more discovery programs, including design and oversight of preclinical experiments leading to viable diagnostic and therapeutic clinical candidates.  The ideal candidate will have experience with radiopharmaceutical development.

We are an early-stage company, so this is a highly visible and impactful role in our growing organization. The ideal candidate will be a self-starter with the desire to collaborate cross-functionally and strive in a fast-paced environment.

Some specific duties and tasks include, but are not limited to, the following:

  • Lead discovery efforts for the development of targeted radiopharmaceuticals
  • Design and oversee preclinical experiments to demonstrate in vitroactivities and in vivo efficacy as well as to define mechanism of action
  • Manage external teams (CROs and academic collaboration) to deliver peptides/peptidomimetics or small molecule-based radiopharmaceutical therapeutics (RPTs) for biological evaluation
  • Matrixed management of scientists and research associates conducting peptide synthesis, biological assays and preclinical studies
  • Interpret and analyze data, prepare, and review study reports, communicate project progress to internal stakeholders and external collaborators
  • Drive key go/no-go decision making
  • Collaborate with CMC and clinical teams for IND filings
  • Represent company at scientific conferences including preparation of data for presentation

Qualifications

  • A PhD in cancer biology, cell or molecular biology, genetics, radiochemistry, medicinal chemistry or a related discipline with relevant post-doctoral training and a proventrack record of scientific excellence and creativity
  • 5+ years of experience in cancer research and drug discovery in biotech or pharmaceutical industries; alternatively, candidates with significant relevant academic research experience will be considered
  • Expertise in cellular and molecular biology techniques, in vitro/in vivomodels for target validation and drug efficacy studies, medicinal chemistry, peptide synthesis, structure-based drug design, and/or synthetic organic chemistry
  • Experience in leading drug discovery projects/program management preferred, but not required
  • Experience in radiopharmaceutical development preferred, but not required
  • Attention to detail with excellent organizational skills, verbal communication and writing skills
  • A team player with excellent interpersonal skills and a strong passion for the discovery of targeted therapies

What’s in it for you

  • Competitive compensation, health and welfare and time off benefits
  • Flexible work environment
  • 20 vacation days, 17 holidays, 5 paid sick days per year
  • Extended health benefits
  • Retirement match
  • Commuter benefits

Schedule

  • Full Time Permanent

Location: Vancouver

Timing: ASAP

Research & Development Chemist

About Us

Alpha-9 Theranostics is a clinical-stage biotechnology company developing radiopharmaceuticals that image and treat solid and hematologic malignancies. Alpha-9 has a portfolio of molecules entering clinical trials and a robust pipeline of additional targets for future development. Building on years of radiopharmaceutical expertise and with backing from leading healthcare investors, Alpha-9 is committed to developing novel radiopharmaceuticals that meaningfully extend patients’ lives.

Position Summary

Alpha-9 is seeking a Chemist to join our growing organization.  The ideal candidate will have experience with solid-phase peptide synthesis, and preferably with radiopharmaceutical development.  This person will be responsible for designing, planning and synthesizing peptides/peptidomimetic building blocks and precursors for radiopharmaceutical product candidates.

We are an early stage company, so you will have the opportunity to participate cross-functionally and contribute to the build-out and set-up of new laboratory facilities.  The ideal candidate will have multi-tasking ability and a desire to strive in a fast-paced environment.

Some specific duties and tasks include, but are not limited to, the following:

  • Design, plan, and synthesize peptides/peptidomimetics or small molecule-based building blocks and drug substances for radiopharmaceutical development
  • Support senior chemists in analytical development and validation using LC-MS/MS, GC-MS, HPLC and NMR
  • Work with internal/external teams to deliver compounds for biological evaluation
  • Maintain clear and accurate lab records
  • Interpret and analyze data, prepare, and review study reports, communicate project progress to internal stakeholders and external collaborators
  • Participate in the writing and execution of patent applications
  • Contribute to build-out and set up of a new laboratory facility
  • Lab maintenance and support of ordering and receipt of needed supplies

Qualifications

  • BS or MS degree in Chemistry or related area; and 0 to 5+ years of related industrial experience
  • Solid understanding and practical experience in synthetic organic methodology and chemical process research, combined with strong problem-solving skills
  • Experience in modern synthetic and analytical techniques
  • Experience with solid-phase peptide synthesis preferred, but not required
  • Experience in radiopharmaceutical development preferred, but not required
  • Excellent observational, organizational, data management, and documentation skills
  • A team player with excellent interpersonal skills and a strong passion for the discovery of targeted therapies in a fast-paced start-up environment

What’s in it for you

  • Competitive compensation, health and welfare and time off benefits
  • 20 vacation days, 17 holidays, 5 paid sick days per year
  • Extended health benefits
  • Retirement match
  • Commuter benefits

Schedule

  • Full Time Permanent

Location: Vancouver

Timing: ASAP

Research & Development Chemist III

About Us

Alpha-9 Theranostics is a clinical-stage biotechnology company developing radiopharmaceuticals that image and treat solid and hematologic malignancies. Alpha-9 has a portfolio of molecules entering clinical trials and a robust pipeline of additional targets for future development. Building on years of radiopharmaceutical expertise and with backing from leading healthcare investors, Alpha-9 is committed to developing novel radiopharmaceuticals that meaningfully extend patients’ lives.

Position Summary

Alpha-9 is seeking an experienced Chemist to join our growing organization.  The ideal candidate will have significant experience with solid-phase peptide synthesis, and preferably with radiopharmaceutical development.  This person will be responsible for designing, planning, and synthesizing peptides/peptidomimetic building blocks and precursors for radiopharmaceutical product candidates and mentoring other chemists.

We are an early-stage company, so you will have the opportunity to participate cross-functionally and contribute to the build-out and set-up of new laboratory facilities.  The ideal candidate will have multi-tasking ability and a desire to strive in a fast-paced environment.

Some specific duties and tasks include, but are not limited to, the following:

  • Design, plan, and synthesize peptides/peptidomimetics or small molecule-based building blocks and drug substances for radiopharmaceutical development
  • Analytical development and validation using LC-MS/MS, GC-MS, HPLC and NMR
  • Partner and collaborate with internal/external teams to deliver compounds for biological evaluation
  • Maintain clear and accurate lab records
  • Interpret and analyze data, prepare, and review study reports, communicate project progress to internal stakeholders and external collaborators
  • Key participant in the writing and execution of patent applications
  • Contribute to build-out and set up of a new laboratory facility
  • Mentor Chemists I and II
  • Lab maintenance and support of ordering and receipt of needed supplies

Qualifications

  • MS or Ph.D. degree in Chemistry or related area; and 5+ years of related industrial experience
  • Solid understanding and practical experience in synthetic organic methodology and chemical process research, combined with strong problem-solving skills
  • Significant experience in modern synthetic and analytical techniques
  • Significant experience with solid-phase peptide synthesis preferred, but not required
  • Significant experience in radiopharmaceutical development preferred, but not required
  • Excellent observational, organizational, data management, and documentation skills
  • A team player with excellent interpersonal skills and a strong passion for the discovery of targeted therapies in a fast-paced start-up environment

What’s in it for you

  • Competitive compensation, health and welfare and time off benefits
  • 20 vacation days, 17 holidays, 5 paid sick days per year
  • Extended health benefits
  • Retirement match
  • Commuter benefits

Schedule

  • Full Time Permanent

Location: Vancouver

Timing: ASAP

Manager, Intellectual Property

About Us

Alpha-9 Theranostics is a clinical-stage biotechnology company developing radiopharmaceuticals that image and treat solid and hematologic malignancies. Alpha-9 has a portfolio of molecules entering clinical trials and a robust pipeline of additional targets for future development. Building on years of radiopharmaceutical expertise and with backing from leading healthcare investors, Alpha-9 is committed to developing novel radiopharmaceuticals that meaningfully extend patients’ lives.

Position Summary

Alpha-9 is seeking a Manager of Intellectual Property (IP) to oversee our global patent portfolio.  This person will be responsible for patent drafting and will serve as the primary point of contact with external IP counsel.  The ideal candidate will have prior experience in the IP department of a life-sciences company or in a law firm.

We are seeking a self-starter capable of working with a high degree of autonomy to join our expanding team.  As a start-up organization, we value team members eager to make an impact and grow with us professionally.

Some specific duties and tasks include, but are not limited to, the following:

  • Draft and prosecute world-wide patent applications in conjunction with external patent counsel.
  • Function as a liaison between research scientists and external patent counsel during patent drafting and prosecution.
  • Perform patentability and freedom to operate searches using patent and scientific literature databases.
  • Actively monitor and analyze competitive intellectual property and communicate findings to R&D project teams and management.
  • Analyze third-party patent portfolios and the related patent landscape to support business development.
  • Attend R&D meetings to identify new patentable matter and collaborate with scientists in drafting of invention disclosures.
  • Provide periodic updates to stakeholders including the R&D project teams, management, and external licensing partners.
  • Proactively prioritize and execute IP functional goals.

Qualifications

  • An advanced degree in chemistry, biochemistry, radiochemistry, medicinal chemistry, pharmaceutical sciences, or a related discipline is required. A PhD and post-doctoral experience preferred.
  • At least 3 years experience in a law firm and/or in-house IP department with a focus on drafting and prosecuting PCT, US and foreign patent applications.
  • Experience searching patent and scientific literature databases.
  • Demonstrated ability to influence others using data, logic, and tailoring messaging to the audience.
  • Strong communication skills, ability to build strong relationships at all levels of the organization.
  • Strong project management skills, including ability to execute versus deadlines and influence without direct reporting relationship.
  • Attention to detail with excellent organizational skills, verbal communication and writing skills.

What’s in it for you

  • Competitive compensation, health and welfare and time off benefits
  • Flexible work environment
  • 20 vacation days, 17 holidays, 5 paid sick days per year
  • Medical, dental and vision insurance
  • Retirement match
  • Commuter benefits

Schedule

  • Full Time Permanent

Location: Boston

Timing: ASAP

Senior Manager, Accounting & FP&A

About Us

Alpha-9 Theranostics is a clinical-stage biotechnology company developing radiopharmaceuticals that image and treat solid and hematologic malignancies. Alpha-9 has a portfolio of molecules entering clinical trials and a robust pipeline of additional targets for future development. Building on years of radiopharmaceutical expertise and with backing from leading healthcare investors, Alpha-9 is committed to developing novel radiopharmaceuticals that meaningfully extend patients’ lives.

Position Summary

Alpha-9 is seeking a Senior Manager, Accounting and FP&A to oversee day to day accounting (led by an external party) as well as supporting financial planning, forecasting, reporting and analysis. The role has responsibilities for the global financial and accounting operations of the company, including subsidiaries in Canada and Australia.

As a start-up organization, we value team members eager to make an impact and grow with us professionally. We are seeking an individual who enjoys multi-tasking and has the willingness and flexibility to assume additional responsibilities as they come up. As an early member of a growing organization, the candidate will help grow the finance department to meet the evolving needs of the company.

Some specific duties and tasks include, but are not limited to, the following:

  • Manage the budget process through interaction with finance and functional colleagues
  • Own reporting of financial results and comparisons to budgets, including variance analyses and development of presentation materials
  • Play key role in the review of the monthly close process, including the reconciliation of transactions, and working with project owners to develop monthly accruals
  • Drive the year-end audit and serve as the main point of contact for the external auditors
  • Support tax filing preparation and transfer pricing accounting by third party tax accountants
  • Responsible for hierarchy and scalability in chart of accounts and accuracy in the general ledger and financial statements
  • Partner on development and implementation of financial process improvements including ways of leveraging corporate financial capabilities
  • Establish documentation of finance processes and controls

Qualifications

  • Bachelor’s degree in Finance, Accounting, or other relevant discipline. CPA preferred
  • 5-8 years of overall business work experience, with some work experience or demonstrated facility with financial planning and analysis, or business partnering/project management.
  • Experience working in life sciences industry setting is preferred
  • Understanding of accounting and GAAP/IFRS accounting principles
  • Strong analytical skills and ability to balance strategic thinking with bottoms-up detailed analysis
  • Proficiency with QuickBooks Online or equivalent financial system required
  • Advanced Microsoft Excel skills required. Proficiency with Microsoft Word and PowerPoint.
  • Excellent written and verbal communication skills
  • Ability to effectively collaborate with others to reach mutually agreeable outcomes and resolve potential conflicts
  • Ability to build strong relationships at all levels of the organization.

What’s in it for you

  • Competitive compensation, health and welfare and time off benefits
  • Flexible work environment
  • 20 vacation days, 17 holidays, 5 paid sick days per year
  • Medical, dental and vision insurance
  • Retirement match
  • Commuter benefits

Schedule

  • Full Time Permanent

Location: Boston

Timing: ASAP

To apply, use the form below.

Don’t see anything that matches your experience? Email us at careers@alpha9tx.com

"*" indicates required fields

Drop files here or
Max. file size: 50 MB, Max. files: 2.